Type I (Insulin-dependent) Diabetic Multiplex Families: Mode of Genetic Transmission
نویسندگان
چکیده
منابع مشابه
Type I (insulin-dependent) diabetic multiplex families: mode of genetic transmission.
HLA genotypes have been analyzed in 120 classic type I (insulin-dependent) diabetic sib pairs with an age of onset below 16 yr reported to the British Diabetic Association register (1972--78). By this age, siblings of diabetic children are 26 times more likely to develop type I diabetes than other children. There is a highly significant disturbance in the zygotic assortment of HLA haplotypes in...
متن کاملInsulin-Dependent Diabetic Multiplex Kindreds
This work was presented in part to the 36th National Nleeting ofthe American Diabetes Association, San Francisco, 20-22 June 1976, and the 1st Congress of HLA and Disease, Paris, 23-25 June 1976. Received for publication 18 February 1977 and in revised form 15 July 1977. These data are compatible with the theory of genetic heterogeneity ofjuvenile, insulini-depenident diabetes. It is suggested ...
متن کاملIndividuals from multiplex insulin-dependent diabetes mellitus (IDDM) families express higher levels of TCRBV2S1 than controls.
T lymphocytes recognise peptide antigens through the T cell antigen receptor, which is composed of variable alpha and beta chains. There are forty-six functional variable regions on the beta chain. In this study the expression of the T cell receptor beta-chain variable regions 2S1 and 3S1, in a large cohort of multiplex insulin-dependent diabetes mellitus families, have been determined by use o...
متن کاملInsulin independence after islet transplantation into type I diabetic patient.
Effective clinical trials of islet transplantation have been limited by the inability to transplant enough viable human islets into patients with type I (insulin-dependent) diabetes mellitus to eliminate their exogenous insulin requirement. We report the first type I diabetic patient with an established kidney transplant on basal cyclosporin immunosuppression who was able to eliminate the insul...
متن کاملApplications of multiplex ligation-dependent probe amplification (MLPA) method in diagnosis of cancer and genetic disorders
Introduction: Lots of human diseases and syndromes result from partial or complete gene deletions and duplications or changes of certain specific chromosomal sequences. Many various methods are used to study the chromosomal aberrations including Comparative Genomic Hybridization (CGH), Fluorescent in Situ Hybridization (FISH), Southern blots, Multiplex Amplifiable Probe Hybridisation (MAP...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetes
سال: 1980
ISSN: 0012-1797,1939-327X
DOI: 10.2337/diab.29.12.1036